Selected Publications:

R. van der Meel, S. Chen, J. Zaifman, J.A. Kulkarni, X.R.S. Zhang, Y.K. Tam, M.B. Bally, R.M. Schiffelers, M.A. Ciufolini, P.R. Cullis, Y.Y.C. Tam, Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery, Small. 17 (2021). https://doi.org/10.1002/smll.202103025.

J.A. Kulkarni, D. Witzigmann, S.B. Thomson, S. Chen, B.R. Leavitt, P.R. Cullis, R. van der Meel, The current landscape of nucleic acid therapeutics, Nature Nanotechnology. 16 (2021) 630–643. https://doi.org/10.1038/s41565-021-00898-0.

J.A. Kulkarni, S. Chen, Y.Y.C. Tam, Scalable Production of Lipid Nanoparticles Containing Amphotericin B, Langmuir. 37 (2021) 7312–7319. https://doi.org/10.1021/acs.langmuir.1c00530.

J.A. Kulkarni, S.B. Thomson, J. Zaifman, J. Leung, P.K. Wagner, A. Hill, Y.Y.C. Tam, P.R. Cullis, T.L. Petkau, B.R. Leavitt, Spontaneous, solvent-free entrapment of siRNA within lipid nanoparticles, Nanoscale. 12 (2020) 23959–23966. https://doi.org/10.1039/d0nr06816k.

D. Witzigmann, J.A. Kulkarni, J. Leung, S. Chen, P.R. Cullis, R. van der Meel, Lipid nanoparticle technology for therapeutic gene regulation in the liver, Advanced Drug Delivery Reviews. 159 (2020) 344–363. https://doi.org/10.1016/j.addr.2020.06.026.

J.A. Kulkarni, D. Witzigmann, J. Leung, R. van der Meel, J. Zaifman, M.M. Darjuan, H.M. Grisch-Chan, B. Thöny, Y.Y.C. Tam, P.R. Cullis, Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads, Nanoscale. 11 (2019) 9023–9031. https://doi.org/10.1039/c9nr02004g.

S. Chen, J. Zaifman, J.A. Kulkarni, I. v. Zhigaltsev, Y.K. Tam, M.A. Ciufolini, Y.Y.C. Tam, P.R. Cullis, Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acids, Journal of Controlled Release. 286 (2018) 46–54. https://doi.org/10.1016/j.jconrel.2018.07.026.

J.A. Kulkarni, M.M. Darjuan, J.E. Mercer, S. Chen, R. van der Meel, J.L. Thewalt, Y.Y.C. Tam, P.R. Cullis, On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA, ACS Nano. 12 (2018) 4787–4795. https://doi.org/10.1021/acsnano.8b01516.